Alpha-Ketoglutaric Acid (AKG): Your Cellular Energy Engine

—High-Purity AKG – Scientifically Backed for Anti-Aging, Immune Enhancement, and Sports Performance

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1. Product Introduction

Alpha-Ketoglutaric Acid (AKG), chemically known as α-ketoglutarate, is a naturally occurring organic acid that plays a vital role in metabolic processes within living organisms. It is a key intermediate in the tricarboxylic acid (TCA) cycle and is essential for amino acid synthesis, nitrogen metabolism, and energy production. AKG is widely used in dietary supplements, sports nutrition, and medical applications, earning it the reputation of a "versatile metabolic agent."
With increasing mental workloads and global aging trends, PS has become a widely used, safe, and effective ingredient in dietary supplements, functional foods, and medical nutrition.

Key Features:

   • High purity: Fine powder with over 99% purity, easily soluble in water.

   • Multifunctionality: Supports energy metabolism, antioxidant defense, immune regulation, and anti-aging.

   • Safety: Naturally present in the human body, with high safety and minimal side effects.

 

 

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2. Production Process

Recent advancements have significantly improved the production process of AKG, with key developments including:

 

1. Microbial Fermentation

   • Process: Genetically modified microorganisms (e.g., E. coli or yeast) are used to efficiently convert glucose or other carbon sources into AKG.

   • Advantages: Environmentally friendly, cost-effective, and suitable for large-scale production.

   • Latest Progress: Optimized strains and fermentation conditions have significantly increased yield and purity.

 

2. Chemical Synthesis

   • Process: AKG is synthesized through chemical oxidation using citric acid or cis-aconitic acid as raw materials.

   • Advantages: Mature technology, suitable for high-purity AKG production.

   • Latest Progress: Green chemistry practices have reduced the use of harmful solvents, enhancing sustainability.

 

3. Enzymatic Synthesis

   • Process: Specific enzymes (e.g., ketoglutarate dehydrogenase) catalyze the conversion of substrates into AKG.

   • Advantages: Mild reaction conditions, high selectivity, and fewer by-products.

   • Latest Progress: Immobilized enzyme technology has improved enzyme stability and reusability.

 

4.Purification Techniques

   • Process: Crystallization and chromatography (e.g., high-performance liquid chromatography) are used to purify AKG.

   • Advantages: Enables pharmaceutical-grade high-purity AKG.

   • Latest Progress: Continuous purification technology has improved efficiency and yield.

 

 

 

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3.Latest Research Applications

Recent advancements have significantly improved the production process of AKG, with key developments including:

 

1. Anti-Aging and Longevity

   • Research: AKG activates the AMPK pathway and inhibits the mTOR pathway, delaying cellular aging and extending lifespan in model organisms.

   • Applications: As an anti-aging supplement to address age-related diseases (e.g., osteoporosis, muscle atrophy).

 

2. Sports Nutrition and Recovery

   • Research: AKG reduces post-exercise lactic acid buildup, promotes muscle protein synthesis, and accelerates recovery.

   • Applications: As a sports nutrition supplement to enhance performance and recovery efficiency.

 

3. Immune Regulation

   • Research: AKG modulates the mTOR signaling pathway, enhancing immune cell function and improving infection resistance.

   • Applications: In immune support products to boost immune function.

 

4.Metabolic Health

   • Research: AKG improves metabolic status in chronic kidney disease patients and reduces ammonia toxicity.

   • Applications: As a metabolic health supplement to support kidney and liver function.

 

5.Gut Health

   • Research: AKG serves as a key energy source for intestinal cells, promoting mucosal repair.

   • Applications: In gut health products to improve intestinal barrier function.

 

 

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4. Comparison with Similar Products

In the field of metabolic support and health, AKG is often compared with Citric Acid, Malic Acid, and Succinic Acid. Below is a comparison:

Product	Main Functions	Advantages	Limitations
Alpha-Ketoglutaric Acid (AKG)	Energy metabolism, antioxidant defense, anti-aging, immune regulation, sports recovery	Multifunctional, high safety	Higher production costs
Citric Acid	Energy metabolism, antioxidant defense, food additive	Low cost, wide applications	Limited functionality, no anti-aging effects
Malic Acid	Energy metabolism, fatigue relief, food acidulant	Improves exercise endurance	Limited functionality, no immune regulation
Succinic Acid	Energy metabolism, antioxidant defense, anti-inflammatory	Significant anti-inflammatory effects	Low solubility, limited applications

1. Summary:

   • AKG outperforms other organic acids in terms of functionality and application scope, particularly in anti-aging, immune regulation, and sports recovery.

   • Despite higher production costs, its high added value and broad application prospects give it a competitive edge in the market.

 

 

 

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5. Product Market Prospects

With increasing attention to metabolic health, anti-aging, and sports nutrition, the demand for AKG continues to grow. Its potential in dietary supplements, functional foods, and medical applications is vast. As production processes are further optimized and clinical research deepens, AKG's market share is expected to expand significantly.

 

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Alpha-Ketoglutaric Acid (AKG) Specification

Items	Specification
Description	White to off-white crystalline powder.
Transmittance（%）	≥95.0
Chloride（%）	≤0.02
Sulfate（%）	≤0.02
Iron（ppm）	≤30
Loss on drying（%）	≤1.0
Residue on ignition（%）	≤0.2
Heavy Metal（ppm）	≤10
Arsenic（ppm）	≤1
Assay（%）	≥98.0
Total plate counts（cfu/g）	≤1000
Yeast and Mould（cfu/g）	≤100
Cholera resistant gram-negative bacteria (cfu/g)	≤10
E.coli	Absence/g
Salmonella	Absence/10g

 

 

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FAQs

 

   Q: Do you have a USA warehouse?

    A: Yes, we have two warehouses in California and tons of inventory.

 

 

   Q: What are the key competitive advantages of Alpha-Ketoglutaric Acid (AKG) offered by JX Nutritional Chemical Co., Limited?

    A: We have a comprehensive quality system and third-party certifications
        1. DMF, ISO, and GMP                2. Kosher, Halal                3. Third-party lab                4. GMO-free                5. OEM service

 

 

   Q: What are the specifications of JX Nutritional Chemical Co., Limited’s Alpha-Ketoglutaric Acid products?

    A: We offer a high-quality, fine powder Alpha-Ketoglutaric Acid (AKG) products feature ≥99% purity, white crystalline powder form, excellent water solubility, and certifications including GMP, USP, and EP, suitable for dietary supplements, sports nutrition, and pharmaceutical applications..

 

 

 

If you're interested in Alpha-Ketoglutaric Acid (AKG) into your supplement formulations, please reach out to JX Nutritional Chemical Co., Limited team. We will reply you as soon as possible.