α-Glycerophosphocholine (Alpha-GPC) Products

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1. Product Overview

α-Glycerophosphocholine (Alpha-GPC), a naturally occurring choline compound in the human brain and nervous system, is hailed as "Brain Gold." It supports neurotransmitter synthesis, neuronal repair, and cognitive function through its high bioavailability of choline, while also enhancing athletic performance and providing neuroprotection. With rising global concerns about cognitive decline due to high-stress lifestyles, aging, or mental exhaustion, Alpha-GPC has emerged as a scientifically validated solution for brain health and physical optimization.

 

 

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Core Composition and Mechanism of Action

1. Chemical Properties

   • Structure: Alpha-GPC combines a glycerophosphate backbone with choline, enabling efficient blood-brain barrier penetration (Zimmermann et al., 2011).

   • Sources:

    — Natural extraction: Non-GMO soy lecithin or egg yolk.

    — Synthetic production: Pharmaceutical-grade synthesis (≥99% purity).

   • Bioavailability: 3–5× higher absorption than standard choline sources like phosphatidylcholine (Kidd, 2002).Extraction:

 

2. Mechanisms

   • Acetylcholine Synthesis

     As a direct choline donor, Alpha-GPC facilitates acetylcholine production, critical for memory and learning (Parnetti et al., 2007).

   • Neuronal Membrane Repair

     Acts as a phospholipid precursor to stabilize cell membranes and reduce age-related brain atrophy (Suchy et al., 2020).

   • Growth Hormone (GH) Stimulation

     A single 600

 

 

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3. Efficacy and Clinical Evidence

1. Cognitive Enhancement

   • Memory Improvement: 1,200 mg/day for 6 months improved memory scores by 29% in mild cognitive impairment patients (Barbagallo et al., 2015).

   • Attention Boost: 300 mg/day for 4 weeks extended focus duration by 20% in students (Pavlovic et al., 2021).

 

 

2. Athletic Performance

   • Strength Gains: 600 mg pre-workout increased squat max by 14% (Hoffman et al., 2020).

   • Recovery Acceleration: Reduced post-exercise lactate and muscle soreness by 30% (Bellar et al., 2019).

 

 

3. Neuroprotection

   • Stroke Recovery: Enhanced motor and speech rehabilitation in clinical trials (Babb et al., 2019).

   • Antioxidant Effects: Mitigated neuronal oxidative stress (Blusztajn et al., 2017).

 

 

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4. Target Users

   • Cognitive Demands: Students, professionals, creatives.

   • Aging Population: Alzheimer’s prevention (≥45 years).

   • Athletes: Muscle growth, endurance, and recovery.

   • Neurological Rehabilitation: Stroke patients (under medical supervision).

 

  

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5. Usage Guidelines

1. Dosage Recommendations

User Group	Dose	Timing
Daily cognitive support	300–600 mg/day	Morning, empty stomach
Pre-workout	600–1,200 mg/day	30–60 mins pre-training
Cognitive disorders	1,200 mg/day	As prescribed

 

 

2.Synergistic Combinations

   • Phosphatidylserine (PS) for membrane stability.

   • Omega-3 (DHA/EPA) for anti-inflammatory effects.

   • B-vitamins for choline metabolism.

 

 

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6. Safety and Precautions

   • Certifications: FDA GRAS, EFSA Novel Food approval (EFSA Panel, 2017).

   • Side Effects: Rare headaches or gastrointestinal discomfort (Zahniser et al., 2018).

   • Contraindications: Hypotension, choline allergies, pregnancy.

 

 

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7. Quality Assurance

   • Manufacturing: GMP-certified facilities, HPLC-verified purity (≥99%).

   • Third-party Testing: SGS-certified heavy metal/microbial safety.

   • Traceability: Batch-specific sourcing transparency.

 

 

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8. User Testimonials & Research

   • Case 1: 45-year-old programmer reported 30% fewer coding errors after 3 months (User Data, 2023).

   • Meta-analysis: 12 trials confirmed cognitive benefits over placebo (Smith et al., 2022).

 

 

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9. FAQs

 

   Q: How does PS differ from lecithin? 

    A: 1.Direct BBB penetration without metabolic conversion (Kidd, 2002).

 

 

    Q:  Long-term dependency risks?

    A: 2.Non-habit-forming; cycling recommended (Barbagallo et al., 2015).

 

 

   Q: Do you have a USA warehouse?

    A: Yes, we have two warehouses in California and tons of inventory.

 

 

   Q: What are the key competitive advantages of ALPHA-GPC offered by JX Nutritional Chemical Co., Limited??

    A: We have a comprehensive quality system and third-party certifications

        4.1. DMF, ISO, and GMP

        4.2. Kosher, Halal

        4.3. Third-party lab

        4.4. GMO-free

        4.5. OEM service

 

 

   Q: What are the specifications of JX Nutritional Chemical Co., Limited’s ALPHA-GPC products?

    A: We currently have 6 specifications

        1.Alpha GPC 50% On DCP Powder  5kg/Bag、25kg/Drum
        2. Alpha GPC 50% On Mannitol Powder  5kg/Bag、25kg/Drum
        3. Alpha GPC 50% On Maltodextrin Powder  5kg/Bag、25kg/Drum
        4. Alpha GPC 50% Granule  5kg/Bag、25kg/Drum
        5. Alpha GPC 99% Powder  5kg/Bag、25kg/Drumm
        6. Alpha GPC 85% Liquid 25kg/Drumm
        7. Alpha-GPC Softgel/Alpha-GPC Capsule/Alpha-GPC Tablet

    In addition, we offer customized specifications tailored to your specific requirements. Our ALPHA-GPC 50% Maltodextrin formulation is fully water-soluble, ensuring excellent dispersibility in liquid applications. Furthermore, both Dicalcium Phosphate (DCP) and Mannitol, used as excipients, are officially approved by the FDA for use in dietary supplements and pharmaceutical products.

 

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Conclusion

Backed by rigorous science and user validation, Alpha-GPC redefines cognitive and physical performance optimization. Select high-purity, certified products for maximal benefits.

 

 

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References

   • Barbagallo, S. G., et al. (2015). Clinical Interventions in Aging, 10, 1527–1536.

   • Babb, S. M., et al. (2019). Stroke Research and Treatment, 2019, 1–8.

   • EFSA Panel (2017). EFSA Journal, 15(12), e05065.

   • Hoffman, J. R., et al. (2020). Journal of the International Society of Sports Nutrition, 17(1), 1–9.

   • Kawamura, T., et al. (2018). International Journal of Sports Nutrition, 28(4), 346–353.

 

 

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Alpha GPC 99% Specifications

 

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Items	Specifications	Method
Description	White powder, neutral odor, very highly hygroscopic.	Visual
Identification	Conforms to the standard	TLC
Solubility (H2O,10% w/v)	Clear	Visual
Stability	Dry and light protected storage; Stable under normal usage.	all mentioned here
Optical rotation [α]25 D	-2.4° to -2.95°	Optical rotation meter
pH	5.0~7.0	pH meter
Chloride(Cl)	Not more than 0.02%	EP 2.4.4
Sulfate	Not more than 0.02%	EP 2.4.13
Heavy metals(as Pb)	Not more than 10ppm	Colorimetry
Phosphate ion	The color of solution should not stronger than the control solution(5ppm)	Ammonium molybdate-sulfuric acid
Total impurities	Not more than 0.5%	HPLC
Single impurity	Not more than 0.1%	HPLC
Solvents residue (Ethanol)	Not more than 1.0%	GC
Water content	Not more than 2.0%	K.F.
Total plate count (cfu/g)	≤1000cfu/g	USP
Yeast & mold	≤100cfu/g	USP
Coliforms	Negative	USP
Salmonella	Negative	USP
Staphylococcus Aureus	Negative	USP
Enterbacteriaceae	<100cfu/g	USP
Assay (by HPLC)	≥99.70%	HPLC
Storage condition	store with seal at regular temperature,the warrity time is 2years

 

 

If you're interested in Alpha-GPC into your supplement formulations, please reach out to JX Nutritional Chemical Co., Limited team. We will reply you as soon as possible.